|Application ||WB, E|
|Calculated MW||30481 Da|
|Antigen Region||205-231 aa|
|Other Names||Osteoclast-associated immunoglobulin-like receptor, Osteoclast-associated receptor, hOSCAR, Polymeric immunoglobulin receptor 3, PIgR-3, PIgR3, Poly-Ig receptor 3, OSCAR|
|Target/Specificity||This OSCAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-231 amino acids from the C-terminal region of human OSCAR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OSCAR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.|
|Cellular Location||Isoform 1: Secreted.|
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Provided below are standard protocols that you may find useful for product applications.
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Herman, S., et al. Arthritis Rheum. 58(10):3041-3050(2008)
Merck, E., et al. J. Immunol. 176(5):3149-3156(2006)
Kim, K., et al. J. Biol. Chem. 280(42):35209-35216(2005)
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