|Application ||WB, E|
|Other Accession||Q8C669, NP_065702.2|
|Calculated MW||46286 Da|
|Antigen Region||177-204 aa|
|Other Names||E3 ubiquitin-protein ligase pellino homolog 1, Pellino-1, 632-, Pellino-related intracellular-signaling molecule, PELI1, PRISM|
|Target/Specificity||This PELI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-204 amino acids from the Central region of human PELI1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PELI1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Scaffold protein involved in the IL-1 signaling pathway via its interaction with the complex containing IRAK kinases and TRAF6. Required for NF-kappa-B activation and IL-8 gene expression in response to IL-1.
Ordureau, A., et al. Biochem. J. 409(1):43-52(2008)
Butler, M.P., et al. J. Biol. Chem. 282(41):29729-29737(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Choi, K.C., et al. Nat. Immunol. 7(10):1057-1065(2006)
Butler, M.P., et al. J. Biol. Chem. 280(30):27759-27768(2005)
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