|Application ||WB, E|
|Other Accession||Q8C669, NP_065702.2|
|Calculated MW||46286 Da|
|Antigen Region||177-204 aa|
|Other Names||E3 ubiquitin-protein ligase pellino homolog 1, Pellino-1, 632-, Pellino-related intracellular-signaling molecule, PELI1, PRISM|
|Target/Specificity||This PELI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-204 amino acids from the Central region of human PELI1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PELI1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.|
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Provided below are standard protocols that you may find useful for product applications.
Scaffold protein involved in the IL-1 signaling pathway via its interaction with the complex containing IRAK kinases and TRAF6. Required for NF-kappa-B activation and IL-8 gene expression in response to IL-1.
Ordureau, A., et al. Biochem. J. 409(1):43-52(2008)
Butler, M.P., et al. J. Biol. Chem. 282(41):29729-29737(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Choi, K.C., et al. Nat. Immunol. 7(10):1057-1065(2006)
Butler, M.P., et al. J. Biol. Chem. 280(30):27759-27768(2005)
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