|Application ||WB, E|
|Calculated MW||47075 Da|
|Antigen Region||230-257 aa|
|Other Names||Perilipin-3, 47 kDa mannose 6-phosphate receptor-binding protein, 47 kDa MPR-binding protein, Cargo selection protein TIP47, Mannose-6-phosphate receptor-binding protein 1, Placental protein 17, PP17, PLIN3, M6PRBP1, TIP47|
|Target/Specificity||This PLIN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-257 amino acids from the Central region of human PLIN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLIN3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.|
|Cellular Location||Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet. Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails|
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Provided below are standard protocols that you may find useful for product applications.
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.
Hocsak, E., et al. FEBS Lett. 584(13):2953-2960(2010)
Bauby, H., et al. Traffic 11(4):455-467(2010)
Kimmel, A.R., et al. J. Lipid Res. 51(3):468-471(2010)
Espinosa, E.J., et al. Cell 137(5):938-948(2009)
Bulankina, A.V., et al. J. Cell Biol. 185(4):641-655(2009)
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