|Application ||WB, E|
|Calculated MW||94300 Da|
|Antigen Region||678-704 aa|
|Other Names||Prickle-like protein 1, REST/NRSF-interacting LIM domain protein 1, PRICKLE1, RILP|
|Target/Specificity||This PRICKLE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 678-704 amino acids from the C-terminal region of human PRICKLE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRICKLE1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.|
|Cellular Location||Nucleus membrane. Cytoplasm, cytosol. Note=A smaller amount is detected in the cytosol|
|Tissue Location||Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
Smith, N.L., et al. Circ Cardiovasc Genet 3(3):256-266(2010)
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Perry, J.R., et al. Diabetes 58(6):1463-1467(2009)
Narimatsu, M., et al. Cell 137(2):295-307(2009)
Shimojo, M. J. Biol. Chem. 283(50):34880-34886(2008)
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