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PTPLAD1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P035 |
| Other Accession | Q8K2C9, A7YY55, NP_057479.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43160 Da |
| Antigen Region | 32-58 aa |
| Gene ID | 51495 |
|---|---|
| Other Names | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3, 3-hydroxyacyl-CoA dehydratase 3, HACD3, Butyrate-induced protein 1, B-ind1, hB-ind1, Protein tyrosine phosphatase-like protein PTPLAD1, Protein-tyrosine phosphatase-like A domain-containing protein 1, PTPLAD1, BIND1, HACD3 |
| Target/Specificity | This PTPLAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-58 amino acids from the N-terminal region of human PTPLAD1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTPLAD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HACD3 {ECO:0000303|PubMed:18554506, ECO:0000312|HGNC:HGNC:24175} |
|---|---|
| Function | Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression.
References
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Taguwa, S., et al. J. Virol. 83(20):10427-10436(2009)
Taguwa, S., et al. J. Virol. 82(6):2631-2641(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Sabbah, M., et al. Gene 374, 128-133 (2006) :
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