|Application ||WB, E|
|Other Accession||P35285, NP_065724.1|
|Calculated MW||21855 Da|
|Antigen Region||166-192 aa|
|Other Names||Ras-related protein Rab-22A, Rab-22, RAB22A, RAB22|
|Target/Specificity||This RAB22A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-192 amino acids from the C-terminal region of human RAB22A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB22A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.|
|Cellular Location||Endosome membrane; Lipid- anchor. Cell membrane; Lipid-anchor. Early endosome. Cell projection, ruffle Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.
Zhu, H., et al. Mol. Biol. Cell 20(22):4720-4729(2009)
Magadan, J.G., et al. Mol. Cell. Biol. 26(7):2595-2614(2006)
Mesa, R., et al. Exp. Cell Res. 304(2):339-353(2005)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Weigert, R., et al. Mol. Biol. Cell 15(8):3758-3770(2004)
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