|Application ||WB, E|
|Calculated MW||43987 Da|
|Antigen Region||308-335 aa|
|Other Names||V-set and immunoglobulin domain-containing protein 4, Protein Z39Ig, VSIG4, CRIg, Z39IG|
|Target/Specificity||This VSIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-335 amino acids from the C-terminal region of human VSIG4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VSIG4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta Expressed in resting macrophages.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
Guo, S., et al. Clin. Immunol. 136(2):282-291(2010)
Van Loo, P., et al. Haematologica 95(3):440-448(2010)
Xu, S., et al. Immunol. Lett. 128(1):46-50(2010)
He, J.Q., et al. Mol. Immunol. 45(16):4041-4047(2008)
Vogt, L., et al. J. Clin. Invest. 116(10):2817-2826(2006)
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