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VSIG4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y279 |
| Other Accession | NP_001171759.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43987 Da |
| Antigen Region | 308-335 aa |
| Gene ID | 11326 |
|---|---|
| Other Names | V-set and immunoglobulin domain-containing protein 4, Protein Z39Ig, VSIG4, CRIg, Z39IG |
| Target/Specificity | This VSIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-335 amino acids from the C-terminal region of human VSIG4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VSIG4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VSIG4 |
|---|---|
| Synonyms | CRIg, Z39IG |
| Function | Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
References
Guo, S., et al. Clin. Immunol. 136(2):282-291(2010)
Van Loo, P., et al. Haematologica 95(3):440-448(2010)
Xu, S., et al. Immunol. Lett. 128(1):46-50(2010)
He, J.Q., et al. Mol. Immunol. 45(16):4041-4047(2008)
Vogt, L., et al. J. Clin. Invest. 116(10):2817-2826(2006)
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