|Application ||WB, E|
|Other Accession||A2VDZ9, NP_004729.1|
|Calculated MW||27228 Da|
|Antigen Region||171-200 aa|
|Other Names||Vesicle-associated membrane protein-associated protein B/C, VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C, VAPB|
|Target/Specificity||This VAPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the C-terminal region of human VAPB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VAPB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type IV membrane protein Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.|
|Tissue Location||Ubiquitous. Isoform 1 predominates.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
Millecamps, S., et al. J. Med. Genet. 47(8):554-560(2010)
Langou, K., et al. J. Neurochem. 114(3):795-809(2010)
Tsai, C.P., et al. Neurobiol. Aging (2010) In press :
Nachreiner, T., et al. Biochem. Biophys. Res. Commun. 394(3):703-708(2010)
Funke, A.D., et al. Clin. Genet. 77(3):302-303(2010)
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