|Application ||WB, E|
|Other Accession||P47752, P52592, NP_004221.3|
|Calculated MW||38867 Da|
|Antigen Region||272-298 aa|
|Other Names||Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5, S1PR2, EDG5|
|Target/Specificity||This S1PR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-298 amino acids from the C-terminal region of human S1PR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||S1PR2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation
Oskeritzian, C.A., et al. J. Exp. Med. 207(3):465-474(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Cattoretti, G., et al. Cancer Res. 69(22):8686-8692(2009)
Randriamboavonjy, V., et al. Basic Res. Cardiol. 104(3):333-340(2009)
Li, M.H., et al. Mol. Cancer Res. 6(10):1649-1656(2008)
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