|Application ||WB, E|
|Calculated MW||34945 Da|
|Antigen Region||68-94 aa|
|Other Names||Growth arrest-specific protein 2, GAS-2, GAS2|
|Target/Specificity||This GAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-94 amino acids from the N-terminal region of human GAS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GAS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth- arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity).|
|Tissue Location||Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Huang, W., et al. Mol. Cell. Biol. 30(19):4575-4594(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Benetti, R., et al. J. Biol. Chem. 280(23):22070-22080(2005)
Tsutsumi, S., et al. Am. J. Hum. Genet. 74(6):1255-1261(2004)
Benetti, R., et al. EMBO J. 20(11):2702-2714(2001)
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