|Application ||WB, E|
|Calculated MW||87928 Da|
|Antigen Region||113-142 aa|
|Other Names||Zinc finger and BTB domain-containing protein 17, Myc-interacting zinc finger protein 1, Miz-1, Zinc finger protein 151, Zinc finger protein 60, ZBTB17, MIZ1, ZNF151, ZNF60|
|Target/Specificity||This ZBTB17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-142 amino acids from the N-terminal region of human ZBTB17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZBTB17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MIZ1, ZNF151, ZNF60|
|Function||Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).|
|Tissue Location||Expressed in germinal center B-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq].
Licchesi, J.D., et al. Oncogene 29(44):5923-5934(2010)
Miao, L., et al. Oncogene 29(5):711-722(2010)
Liu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(43):18279-18284(2009)
Basu, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(5):1433-1438(2009)
Ikegaki, N., et al. Clin. Cancer Res. 13(20):6001-6009(2007)
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