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ITPA Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ITPA Antibody (C-term) AP18963b
    ITPA Antibody (C-term) (Cat. #AP18963b) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the ITPA antibody detected the ITPA protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BY32
Other Accession NP_258412.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21446 Da
Antigen Region 149-178 aa
Additional Information
Gene ID 3704
Other Names Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, ITPase {ECO:0000255|HAMAP-Rule:MF_03148}, Inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, 36119 {ECO:0000255|HAMAP-Rule:MF_03148}, Non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, NTPase {ECO:0000255|HAMAP-Rule:MF_03148}, Putative oncogene protein hlc14-06-p, ITPA {ECO:0000255|HAMAP-Rule:MF_03148}, C20orf37
Target/Specificity This ITPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the C-terminal region of human ITPA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITPA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITPA {ECO:0000255|HAMAP-Rule:MF_03148}
Synonyms C20orf37
Function Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832}
Tissue Location Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland
Research Areas
Citations (0)

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The protein encoded by this gene hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding.


Kim, J.H., et al. J. Clin. Gastroenterol. 44 (10), E242-E248 (2010) :
Ochi, H., et al. Gastroenterology 139(4):1190-1197(2010)
Thompson, A.J., et al. Gastroenterology 139(4):1181-1189(2010)
Ban, H., et al. J. Gastroenterol. 45(10):1014-1021(2010)
Fellay, J., et al. Nature 464(7287):405-408(2010)

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$ 295.00
$ 99.00
Cat# AP18963b
(40 western blots)
Availability: In Stock
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