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>   home   >   Products   >   Primary Antibodies   >   SLCO1B3 Antibody (C-term)   

SLCO1B3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SLCO1B3 Antibody (C-term) AP18964b
    All lanes : Anti-SLCO1B3 Antibody (C-term) at 1:2000 dilution Lane 1: NCI-H460 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - SLCO1B3 Antibody (C-term) AP18964b
    All lanes : Anti-SLCO1B3 Antibody (C-term) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: SW480 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - SLCO1B3 Antibody (C-term) AP18964b
    All lanes : Anti-SLCO1B3 Antibody (C-term) at 1:2000 dilution Lane 1: human liver lysates Lane 2: human ovary lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - SLCO1B3 Antibody (C-term) AP18964b
    All lanes : Anti-SLCO1B3 Antibody (C-term) at 1:2000 dilution Lane 1: Hela whole cell lysates Lane 2: PC-3 whole cell lysates Lane 3: SW480 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - SLCO1B3 Antibody (C-term) AP18964b
    Anti-SLCO1B3 Antibody (C-term)at 1:1000 dilution + NCI-H460 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - SLCO1B3 Antibody (C-term) AP18964b
    SLCO1B3 Antibody (C-term) (Cat. #AP18964b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SLCO1B3 antibody detected the SLCO1B3 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NPD5
Other Accession NP_062818.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 77403 Da
Antigen Region 639-668 aa
Additional Information
Gene ID 28234
Other Names Solute carrier organic anion transporter family member 1B3, Liver-specific organic anion transporter 2, LST-2, Organic anion transporter 8, Organic anion-transporting polypeptide 8, OATP-8, Solute carrier family 21 member 8, SLCO1B3, LST2, OATP1B3, OATP8, SLC21A8
Target/Specificity This SLCO1B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639-668 amino acids from the C-terminal region of human SLCO1B3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLCO1B3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLCO1B3
Synonyms LST2, OATP1B3, OATP8, SLC21A8
Function Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Cellular Location Basolateral cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder
Citations (0)

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Background

SLCO1B3 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).

References

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Weiner, M., et al. Antimicrob. Agents Chemother. 54(10):4192-4200(2010)
Kang, T.W., et al. Hum. Mol. Genet. 19(18):3672-3678(2010)
Takahashi, N., et al. J. Hum. Genet. (2010) In press :
Justenhoven, C., et al. Breast Cancer Res. Treat. (2010) In press :

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$ 295.00
$ 99.00
Cat# AP18964b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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