|Application ||WB, E|
|Calculated MW||77403 Da|
|Antigen Region||639-668 aa|
|Other Names||Solute carrier organic anion transporter family member 1B3, Liver-specific organic anion transporter 2, LST-2, Organic anion transporter 8, Organic anion-transporting polypeptide 8, OATP-8, Solute carrier family 21 member 8, SLCO1B3, LST2, OATP1B3, OATP8, SLC21A8|
|Target/Specificity||This SLCO1B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639-668 amino acids from the C-terminal region of human SLCO1B3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLCO1B3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LST2, OATP1B3, OATP8, SLC21A8|
|Function||Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder|
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Provided below are standard protocols that you may find useful for product applications.
SLCO1B3 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Weiner, M., et al. Antimicrob. Agents Chemother. 54(10):4192-4200(2010)
Kang, T.W., et al. Hum. Mol. Genet. 19(18):3672-3678(2010)
Takahashi, N., et al. J. Hum. Genet. (2010) In press :
Justenhoven, C., et al. Breast Cancer Res. Treat. (2010) In press :
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