|Application ||WB, E|
|Calculated MW||76024 Da|
|Antigen Region||5-34 aa|
|Other Names||Synaptotagmin-like protein 4, Exophilin-2, Granuphilin, SYTL4|
|Target/Specificity||This SYTL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-34 amino acids from the N-terminal region of human SYTL4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYTL4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).|
|Cellular Location||Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.
Plaisance, V., et al. J. Biol. Chem. 281(37):26932-26942(2006)
Ciufo, L.F., et al. Mol. Biol. Cell 16(2):470-482(2005)
Fukuda, M. J. Biol. Chem. 278(17):15390-15396(2003)
Fukuda, M., et al. J. Biol. Chem. 277(42):39673-39678(2002)
Torii, S., et al. Mol. Cell. Biol. 22(15):5518-5526(2002)
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