|Application ||WB, E|
|Other Accession||P56451, B0V1P1, NP_005904.1, P41983|
|Calculated MW||36601 Da|
|Antigen Region||280-308 aa|
|Other Names||Melanocortin receptor 5, MC5-R, MC-2, MC5R|
|Target/Specificity||This MC5R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-308 amino acids from the C-terminal region of human MC5R.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MC5R Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in the brain but not in the melanoma cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Miller, C.L., et al. Schizophr. Res. 113 (2-3), 259-267 (2009) :
Frandberg, P.A., et al. Biochem. Biophys. Res. Commun. 236(2):489-492(1997)
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