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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GCHFR Antibody (C-term)   

GCHFR Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GCHFR Antibody (C-term) AP18973b
    GCHFR Antibody (C-term) (Cat. #AP18973b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GCHFR antibody detected the GCHFR protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P30047
Other Accession Q32L41, NP_005249.1
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 9698 Da
Antigen Region 38-66 aa
Additional Information
Gene ID 2644
Other Names GTP cyclohydrolase 1 feedback regulatory protein, GFRP, GTP cyclohydrolase I feedback regulatory protein, p35, GCHFR, GFRP
Target/Specificity This GCHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the C-terminal region of human GCHFR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGCHFR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCHFR
Synonyms GFRP
Function Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Cellular Location Nucleus. Nucleus membrane. Cytoplasm, cytosol
Tissue Location In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
Research Areas
Citations (0)

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Background

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) McHugh, P.C., et al. Pharmacogenomics J. (2010) In press : Li, L., et al. Circ. Res. 106(2):328-336(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8(8):753-757(2009)

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Cat# AP18973b
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(40 western blots)
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