|Application ||WB, E|
|Other Accession||Q32L41, NP_005249.1|
|Calculated MW||9698 Da|
|Antigen Region||38-66 aa|
|Other Names||GTP cyclohydrolase 1 feedback regulatory protein, GFRP, GTP cyclohydrolase I feedback regulatory protein, p35, GCHFR, GFRP|
|Target/Specificity||This GCHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the C-terminal region of human GCHFR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GCHFR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.|
|Cellular Location||Nucleus. Nucleus membrane. Cytoplasm, cytosol|
|Tissue Location||In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) McHugh, P.C., et al. Pharmacogenomics J. (2010) In press : Li, L., et al. Circ. Res. 106(2):328-336(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8(8):753-757(2009)
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