|Application ||WB, E|
|Calculated MW||61454 Da|
|Antigen Region||299-327 aa|
|Other Names||Amyloid beta A4 precursor protein-binding family A member 3, Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3, Mint-3, APBA3, MINT3, X11L2|
|Target/Specificity||This APBA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the Central region of human APBA3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APBA3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.|
|Cellular Location||Cytoplasm, perinuclear region|
|Tissue Location||Expressed in all tissues examined with lower levels in brain and testis|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010) Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009) Sakamoto, T., et al. J. Biol. Chem. 284(44):30350-30359(2009) Han, J., et al. J. Cell. Sci. 121 (PT 13), 2217-2223 (2008) : Shrivastava-Ranjan, P., et al. Mol. Biol. Cell 19(1):51-64(2008)
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