|Application ||WB, E|
|Calculated MW||29266 Da|
|Antigen Region||197-225 aa|
|Other Names||Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR, PTCRA|
|Target/Specificity||This PTCRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-225 amino acids from the C-terminal region of human PTCRA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTCRA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
In immature T cells the T-cell receptor beta-chain gene (TCRB; MIM 186930) is rearranged and expressed before the TCRA (MIM 186880) chain. At this early stage, TCRB can associate with the pre-T-cell receptor alpha chain (PTCRA). The PTCRA, together with TCRB and the CD3 complex (see MIM 186740), minimally make up the pre-T cell receptor (pre-TCR), which regulates early T cell development.
Velez, D.R., et al. Am. J. Obstet. Gynecol. 200 (2), 209 (2009) :
Menon, R., et al. Reprod. Biol. Endocrinol. 7, 62 (2009) :
Velez, D.R., et al. PLoS ONE 3 (9), E3283 (2008) :
Navarro, M.N., et al. Blood 110(13):4331-4340(2007)
Bas, A., et al. J. Immunol. 171(7):3359-3371(2003)
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