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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTCRA Antibody (C-term)   

PTCRA Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PTCRA Antibody (C-term) AP18980B
    PTCRA Antibody (C-term) (Cat. #AP18980b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PTCRA antibody detected the PTCRA protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ISU1
Other Accession NP_612153.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 29266 Da
Antigen Region 197-225 aa
Additional Information
Gene ID 171558
Other Names Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR, PTCRA
Target/Specificity This PTCRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-225 amino acids from the C-terminal region of human PTCRA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTCRA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow
Research Areas
Citations (0)

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In immature T cells the T-cell receptor beta-chain gene (TCRB; MIM 186930) is rearranged and expressed before the TCRA (MIM 186880) chain. At this early stage, TCRB can associate with the pre-T-cell receptor alpha chain (PTCRA). The PTCRA, together with TCRB and the CD3 complex (see MIM 186740), minimally make up the pre-T cell receptor (pre-TCR), which regulates early T cell development.


Velez, D.R., et al. Am. J. Obstet. Gynecol. 200 (2), 209 (2009) :
Menon, R., et al. Reprod. Biol. Endocrinol. 7, 62 (2009) :
Velez, D.R., et al. PLoS ONE 3 (9), E3283 (2008) :
Navarro, M.N., et al. Blood 110(13):4331-4340(2007)
Bas, A., et al. J. Immunol. 171(7):3359-3371(2003)

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Cat# AP18980B
(40 western blots)
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