|Application ||WB, E|
|Calculated MW||29266 Da|
|Antigen Region||197-225 aa|
|Other Names||Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR, PTCRA|
|Target/Specificity||This PTCRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-225 amino acids from the C-terminal region of human PTCRA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTCRA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
In immature T cells the T-cell receptor beta-chain gene (TCRB; MIM 186930) is rearranged and expressed before the TCRA (MIM 186880) chain. At this early stage, TCRB can associate with the pre-T-cell receptor alpha chain (PTCRA). The PTCRA, together with TCRB and the CD3 complex (see MIM 186740), minimally make up the pre-T cell receptor (pre-TCR), which regulates early T cell development.
Velez, D.R., et al. Am. J. Obstet. Gynecol. 200 (2), 209 (2009) :
Menon, R., et al. Reprod. Biol. Endocrinol. 7, 62 (2009) :
Velez, D.R., et al. PLoS ONE 3 (9), E3283 (2008) :
Navarro, M.N., et al. Blood 110(13):4331-4340(2007)
Bas, A., et al. J. Immunol. 171(7):3359-3371(2003)
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