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KCTD17 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N5Z5 |
| Other Accession | NP_078957.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34888 Da |
| Antigen Region | 107-136 aa |
| Gene ID | 79734 |
|---|---|
| Other Names | BTB/POZ domain-containing protein KCTD17, KCTD17 |
| Target/Specificity | This KCTD17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the Central region of human KCTD17. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCTD17 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCTD17 (HGNC:25705) |
|---|---|
| Function | Substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down- regulation. Thereby, positively regulates ciliogenesis, playing a crucial role in the initial steps of axoneme extension (PubMed:25270598). May also play a role in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in brain. Highest expression is observed in the putamen and the thalamus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Dunham, I., et al. Nature 402(6761):489-495(1999)
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