|Application ||WB, E|
|Calculated MW||56540 Da|
|Antigen Region||434-463 aa|
|Other Names||Tripartite motif-containing protein 35, Hemopoietic lineage switch protein 5, TRIM35, HLS5, KIAA1098|
|Target/Specificity||This TRIM35 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 434-463 amino acids from the C-terminal region of human TRIM35.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM35 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified.
Lalonde, J.P., et al. J. Biol. Chem. 279(9):8181-8189(2004)
Kimura, F., et al. J. Biol. Chem. 278(27):25046-25054(2003)
Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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