|Application ||WB, E|
|Calculated MW||54766 Da|
|Antigen Region||457-486 aa|
|Other Names||E3 ubiquitin-protein ligase TRIM58, 632-, Protein BIA2, Tripartite motif-containing protein 58, TRIM58|
|Target/Specificity||This TRIM58 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from the C-terminal region of human TRIM58.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM58 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.|
|Tissue Location||Expressed in erythroblasts.|
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Provided below are standard protocols that you may find useful for product applications.
TRIM58 belongs to the TRIM/RBCC family of proteins. it contains a B box-type zinc finger domain, a B30.2/SPRY domain and a RING-type zinc finger domian.
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
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