|Application ||WB, E|
|Calculated MW||86453 Da|
|Antigen Region||692-721 aa|
|Other Names||Relaxin receptor 2, G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2, RXFP2, GPR106, GREAT, LGR8|
|Target/Specificity||This RXFP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human RXFP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RXFP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR106, GREAT, LGR8|
|Function||Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Ars, E., et al. Int. J. Androl. (2010) In press :
Ferlin, A., et al. Ann. N. Y. Acad. Sci. 1160, 215-218 (2009) :
Ferlin, A., et al. Ann. N. Y. Acad. Sci. 1160, 213-214 (2009) :
Feng, S., et al. Ann. N. Y. Acad. Sci. 1160, 197-204 (2009) :
Scott, D.J., et al. Ann. N. Y. Acad. Sci. 1160, 74-77 (2009) :
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