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ARPC2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15144 |
| Other Accession | P85970, Q9CVB6, Q3MHR7, NP_690601.1, Q0IH88, Q6IRB1 |
| Reactivity | Human |
| Predicted | Xenopus, Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34333 Da |
| Antigen Region | 263-291 aa |
| Gene ID | 10109 |
|---|---|
| Other Names | Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC, ARPC2, ARC34 |
| Target/Specificity | This ARPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human ARPC2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARPC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARPC2 |
|---|---|
| Synonyms | ARC34 |
| Function | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9CVB6}. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq].
References
Monfregola, J., et al. J. Biol. Chem. 285(22):16951-16957(2010)
Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)
Franke, A., et al. Nat. Genet. 40(11):1319-1323(2008)
Xiao, F., et al. Brain Res. 1233, 168-175 (2008) :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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