|Application ||WB, E|
|Other Accession||P85970, Q9CVB6, Q3MHR7, NP_690601.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||34333 Da|
|Antigen Region||263-291 aa|
|Other Names||Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC, ARPC2, ARC34|
|Target/Specificity||This ARPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human ARPC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARPC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection. Cell junction, synapse, synaptosome|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq].
Monfregola, J., et al. J. Biol. Chem. 285(22):16951-16957(2010)
Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)
Franke, A., et al. Nat. Genet. 40(11):1319-1323(2008)
Xiao, F., et al. Brain Res. 1233, 168-175 (2008) :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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