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CATSPER2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96P56 |
| Other Accession | NP_742095.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62041 Da |
| Antigen Region | 472-500 aa |
| Gene ID | 117155 |
|---|---|
| Other Names | Cation channel sperm-associated protein 2, CatSper2, CATSPER2 |
| Target/Specificity | This CATSPER2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-500 amino acids from the C-terminal region of human CATSPER2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CATSPER2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CATSPER2 |
|---|---|
| Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. |
| Cellular Location | Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:A2ARP9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A2ARP9} |
| Tissue Location | Testis-specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Zhang, D., et al. J. Biol. Chem. 281(31):22332-22341(2006)
Clapham, D.E., et al. Pharmacol. Rev. 57(4):451-454(2005)
Quill, T.A., et al. Proc. Natl. Acad. Sci. U.S.A. 98(22):12527-12531(2001)
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