|Application ||WB, E|
|Other Accession||Q2TBR6, NP_002614.2|
|Calculated MW||15314 Da|
|Antigen Region||4-32 aa|
|Other Names||Prefoldin subunit 4, Protein C-1, PFDN4, PFD4|
|Target/Specificity||This PFDN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human PFDN4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PFDN4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|
|Cellular Location||Nucleus. Cytoplasm. Mitochondrion|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
Simons, C.T., et al. J. Biol. Chem. 279(6):4196-4203(2004)
Martin-Benito, J., et al. EMBO J. 21(23):6377-6386(2002)
Hartl, F.U., et al. Science 295(5561):1852-1858(2002)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Cowan, N.J., et al. Nat. Struct. Biol. 6(11):990-991(1999)
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