|Application ||WB, E|
|Calculated MW||95699 Da|
|Antigen Region||594-623 aa|
|Other Names||Ras GTPase-activating protein 3, GAP1(IP4BP), Ins P4-binding protein, RASA3|
|Target/Specificity||This RASA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-623 amino acids from the C-terminal region of human RASA3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASA3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.|
|Cellular Location||Cell membrane.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
Kupzig, S., et al. Mol. Cell. Biol. 29(14):3929-3940(2009)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Walker, S.A., et al. J. Biol. Chem. 277(50):48779-48785(2002)
Koehler, J.A., et al. Biochem. Biophys. Res. Commun. 283(4):888-895(2001)
Cozier, G.E., et al. J. Biol. Chem. 275(36):28261-28268(2000)
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