|Application ||WB, E|
|Calculated MW||64666 Da|
|Antigen Region||463-492 aa|
|Other Names||Adapter protein CIKS, Connection to IKK and SAPK/JNK, Nuclear factor NF-kappa-B activator 1, ACT1, TRAF3-interacting protein 2, TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6|
|Target/Specificity||This TRAF3IP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human TRAF3IP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRAF3IP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C6orf2, C6orf4, C6orf5, C6orf6|
|Function||Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
Ellinghaus, E., et al. Nat. Genet. 42(11):991-995(2010)
Giltiay, N.V., et al. J. Immunol. 185(1):99-109(2010)
Liu, C., et al. Sci Signal 2 (92), RA63 (2009) :
Li, X. Cytokine 41(2):105-113(2008)
Huang, F., et al. J. Immunol. 179(10):6504-6513(2007)
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