|Application ||WB, E|
|Other Accession||O88291, F1MJM0, NP_892021.1|
|Calculated MW||65654 Da|
|Antigen Region||127-155 aa|
|Other Names||DBIRD complex subunit ZNF326, Zinc finger protein 326, Zinc finger protein interacting with mRNPs and DBC1, ZNF326, ZIRD|
|Target/Specificity||This ZNF326 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the N-terminal region of human ZNF326.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF326 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.|
|Cellular Location||Nucleus matrix.|
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Provided below are standard protocols that you may find useful for product applications.
Probable transcriptional activator which may play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro (By similarity).
O'Donnell, C.J., et al. BMC Med. Genet. 8 SUPPL 1, S4 (2007) :
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
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