|Application ||WB, E|
|Other Accession||Q9NY87, Q9NS25, NP_663698.1|
|Calculated MW||10982 Da|
|Antigen Region||39-65 aa|
|Other Names||Sperm protein associated with the nucleus on the X chromosome E, Nuclear-associated protein SPAN-Xe, SPANX-E, SPANX family member E, SPANXE|
|Target/Specificity||This SPANXE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the Central region of human SPANXE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPANXE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm. Nucleus. Note=Associated with nuclear craters|
|Tissue Location||Detected in testis, sperm and a melanoma cell line.|
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Provided below are standard protocols that you may find useful for product applications.
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that contains a consensus nuclear localization signal but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined.
Hansen, S., et al. Syst Biol Reprod Med 55, 18-26 (2010) :
Kouprina, N., et al. Genome Res. 15(11):1477-1486(2005)
Zendman, A.J., et al. Gene 309(2):125-133(2003)
Westbrook, V.A., et al. Biol. Reprod. 64(1):345-358(2001)
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