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SPESP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6UW49 |
| Other Accession | NP_663633.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38931 Da |
| Antigen Region | 236-262 aa |
| Gene ID | 246777 |
|---|---|
| Other Names | Sperm equatorial segment protein 1, ESP, Equatorial segment protein, SP-ESP, Glycosylated 38 kDa sperm protein C-7/8, SPESP1 |
| Target/Specificity | This SPESP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-262 amino acids from the C-terminal region of human SPESP1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SPESP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPESP1 (HGNC:15570) |
|---|---|
| Function | Involved in fertilization ability of sperm. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (PubMed:12773409). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity) {ECO:0000250|UniProtKB:Q9D5A0, ECO:0000269|PubMed:12773409} |
| Tissue Location | Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The encoded protein is a human alloantigen involved in sperm-egg binding and fusion.
References
Wolkowicz, M.J., et al. J. Androl. 29(3):272-282(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Wolkowicz, M.J., et al. Biol. Reprod. 69(3):735-745(2003)
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