|Application ||WB, E|
|Calculated MW||41450 Da|
|Antigen Region||187-213 aa|
|Other Names||Surfeit locus protein 6, SURF6, SURF-6|
|Target/Specificity||This SURF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-213 amino acids from the Central region of human SURF6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SURF6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Granular component of the nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.
Polzikov, M., et al. Biochem. Biophys. Res. Commun. 327(1):143-149(2005)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Angiolillo, A., et al. Gene 284 (1-2), 169-178 (2002) :
Andersen, J.S., et al. Curr. Biol. 12(1):1-11(2002)
Magoulas, C., et al. Gene 243 (1-2), 115-123 (2000) :
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