|Application ||WB, E|
|Calculated MW||47745 Da|
|Antigen Region||128-154 aa|
|Other Names||Mitochondrial tRNA-specific 2-thiouridylase 1, 281-, MTO2 homolog, TRMU, MTU1, TRMT1|
|Target/Specificity||This TRMU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-154 amino acids from the Central region of human TRMU.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRMU Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.|
|Tissue Location||Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.
Zeharia, A., et al. Am. J. Hum. Genet. 85(3):401-407(2009)
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
de Moraes, V.C., et al. Biochem. Biophys. Res. Commun. 381(2):210-213(2009)
Otaegui, D., et al. Audiol. Neurootol. 13(5):320-327(2008)
Guan, M.X., et al. Am. J. Hum. Genet. 79(2):291-302(2006)
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