TRMU Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O75648 |
Other Accession | NP_060476.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47745 Da |
Antigen Region | 128-154 aa |
Gene ID | 55687 |
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Other Names | Mitochondrial tRNA-specific 2-thiouridylase 1, 281-, MTO2 homolog, TRMU, MTU1, TRMT1 |
Target/Specificity | This TRMU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-154 amino acids from the Central region of human TRMU. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TRMU Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRMU |
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Synonyms | MTU1, TRMT1 |
Function | Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. |
Cellular Location | Mitochondrion |
Tissue Location | Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.
References
Zeharia, A., et al. Am. J. Hum. Genet. 85(3):401-407(2009)
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
de Moraes, V.C., et al. Biochem. Biophys. Res. Commun. 381(2):210-213(2009)
Otaegui, D., et al. Audiol. Neurootol. 13(5):320-327(2008)
Guan, M.X., et al. Am. J. Hum. Genet. 79(2):291-302(2006)
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