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>   home   >   Products   >   Primary Antibodies   >   GAS41 (YEATS4/NuBI-1) Antibody (N-term A31)   

GAS41 (YEATS4/NuBI-1) Antibody (N-term A31)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GAS41 (YEATS4/NuBI-1) Antibody (N-term A31) AP1910a
    Western blot analysis of anti-NuBI-1 Pab (Cat. #AP1910a) in HepG2 cell line lysate. NuBI-1(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95619
Other Accession Q9CR11
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 26499 Da
Antigen Region 16-46 aa
Additional Information
Gene ID 8089
Other Names YEATS domain-containing protein 4, Glioma-amplified sequence 41, Gas41, NuMA-binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41
Target/Specificity This GAS41 (YEATS4/NuBI-1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human GAS41 (YEATS4/NuBI-1).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGAS41 (YEATS4/NuBI-1) Antibody (N-term A31) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GAS41
Function Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00376, ECO:0000269|PubMed:10913114}
Tissue Location Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle
Citations (0)

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NuBI-1 is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. The gene for this protein has been shown to be amplified in tumors.


Cai, Y., et al., J. Biol. Chem. 278(44):42733-42736 (2003).
Lauffart, B., et al., Genomics 81(2):192-201 (2003).
Zimmermann, K., et al., J. Biol. Chem. 277(21):18626-18631 (2002).
Debernardi, S., et al., Blood 99(1):275-281 (2002).
Munnia, A., et al., Oncogene 20(35):4853-4863 (2001).

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Cat# AP1910a
(40 western blots)
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