|Application ||WB, E|
|Calculated MW||128255 Da|
|Antigen Region||26-54 aa|
|Other Names||Replication factor C subunit 1, Activator 1 140 kDa subunit, A1 140 kDa subunit, Activator 1 large subunit, Activator 1 subunit 1, DNA-binding protein PO-GA, Replication factor C 140 kDa subunit, RF-C 140 kDa subunit, RFC140, Replication factor C large subunit, RFC1, RFC140|
|Target/Specificity||This RFC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human RFC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RFC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.|
|Tissue Location||Wide tissue distribution. Undetectable in placental tissue|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability. [provided by RefSeq].
Overmeer, R.M., et al. Mol. Cell. Biol. 30(20):4828-4839(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Arora, M., et al. Leukemia 24(8):1470-1475(2010) Galbiatti, A.L., et al. Mol. Biol. Rep. (2010) In press : Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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