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GNB4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HAV0 |
| Other Accession | O35353, P29387, P79959, P54311, P62874, P62873, P26308, Q6PH57, Q6TMK6, P62871, NP_067642.1 |
| Reactivity | Human |
| Predicted | Bovine, Hamster, Zebrafish, Drosophila, Mouse, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37567 Da |
| Antigen Region | 109-138 aa |
| Gene ID | 59345 |
|---|---|
| Other Names | Guanine nucleotide-binding protein subunit beta-4, Transducin beta chain 4, GNB4 |
| Target/Specificity | This GNB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human GNB4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNB4 |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Tissue Location | Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.
References
Riemann, K., et al. Anticancer Res. 29(4):1271-1274(2009)
Riemann, K., et al. Pharmacogenet. Genomics 18(11):999-1008(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Rosskopf, D., et al. FEBS Lett. 544 (1-3), 27-32 (2003) :
Jiang, G., et al. Am. J. Physiol. Endocrinol. Metab. 284 (4), E671-E678 (2003) :
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