|Application ||WB, E|
|Other Accession||O35353, P29387, P79959, P54311, P62874, P62873, P26308, Q6PH57, Q6TMK6, P62871, NP_067642.1|
|Predicted||Bovine, Hamster, Zebrafish, Drosophila, Mouse, Rat, Xenopus|
|Calculated MW||37567 Da|
|Antigen Region||109-138 aa|
|Other Names||Guanine nucleotide-binding protein subunit beta-4, Transducin beta chain 4, GNB4|
|Target/Specificity||This GNB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human GNB4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.|
|Tissue Location||Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves|
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Provided below are standard protocols that you may find useful for product applications.
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.
Riemann, K., et al. Anticancer Res. 29(4):1271-1274(2009)
Riemann, K., et al. Pharmacogenet. Genomics 18(11):999-1008(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Rosskopf, D., et al. FEBS Lett. 544 (1-3), 27-32 (2003) :
Jiang, G., et al. Am. J. Physiol. Endocrinol. Metab. 284 (4), E671-E678 (2003) :
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