|Application ||WB, E|
|Calculated MW||51124 Da|
|Antigen Region||404-432 aa|
|Other Names||Relaxin-3 receptor 1, RLN3 receptor 1, G protein-coupled receptor SALPR, G-protein coupled receptor GPCR135, Relaxin family peptide receptor 3, Somatostatin- and angiotensin-like peptide receptor, RXFP3, RLN3R1, SALPR|
|Target/Specificity||This RXFP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human RXFP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RXFP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis|
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Provided below are standard protocols that you may find useful for product applications.
RXFP3 is a receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
Huang, Y.W., et al. Gynecol. Oncol. 117(2):239-247(2010)
van der Westhuizen, E.T., et al. Mol. Pharmacol. 77(5):759-772(2010)
Hossain, M.A., et al. Chem Biol Drug Des 73(1):46-52(2009)
Zhu, J., et al. Eur. J. Pharmacol. 590 (1-3), 43-52 (2008) :
Hossain, M.A., et al. J. Biol. Chem. 283(25):17287-17297(2008)
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