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RNF6 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RNF6 Antibody (C-term) AP19165b
    RNF6 Antibody (C-term) (Cat. #AP19165b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RNF6 antibody detected the RNF6 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y252
Other Accession NP_898865.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 78091 Da
Antigen Region 529-558 aa
Additional Information
Gene ID 6049
Other Names E3 ubiquitin-protein ligase RNF6, 632-, RNF6, SPG2
Target/Specificity This RNF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529-558 amino acids from the C-terminal region of human RNF6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRNF6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF6
Synonyms SPG2
Function E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Cellular Location Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells.
Tissue Location Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
Research Areas
Citations (0)

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The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.


Xu, K., et al. Cancer Cell 15(4):270-282(2009)
Zhu, L., et al. Sci. China, C, Life Sci. 51(4):302-307(2008)
Tursun, B., et al. Genes Dev. 19(19):2307-2319(2005)
Lo, H.S., et al. Cancer Res. 62(15):4191-4193(2002)
Lopez, P., et al. Mol. Cell. Biol. 22(10):3488-3496(2002)

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Cat# AP19165b
(40 western blots)
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