|Application ||WB, E|
|Other Accession||P62074, P62073, Q2NKR1, Q6GQ52, Q4QR62, NP_036588.1|
|Predicted||Xenopus, Bovine, Mouse, Rat|
|Calculated MW||10333 Da|
|Antigen Region||21-49 aa|
|Other Names||Mitochondrial import inner membrane translocase subunit Tim10, TIMM10, TIM10|
|Target/Specificity||This TIMM10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the Central region of human TIMM10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIMM10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side|
|Tissue Location||Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
TIMM10 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006) Carey, K.A., et al. Pathol. Int. 56(5):246-255(2006) Webb, C.T., et al. Mol. Cell 21(1):123-133(2006) Muhlenbein, N., et al. J. Biol. Chem. 279(14):13540-13546(2004) Allen, S., et al. J. Biol. Chem. 278(40):38505-38513(2003)
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