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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AKAP5 Antibody (Center)   

AKAP5 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AKAP5 Antibody (Center) AP19171c
    AKAP5 Antibody (Center) (Cat. #AP19171c) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the AKAP5 antibody detected the AKAP5 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24588
Other Accession NP_004848.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47088 Da
Antigen Region 115-143 aa
Additional Information
Gene ID 9495
Other Names A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79
Target/Specificity This AKAP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human AKAP5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAKAP5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKAP5
Synonyms AKAP79
Function May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
Cellular Location Membrane; Lipid-anchor. Note=Associates with lipid rafts
Tissue Location Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary
Research Areas
Citations (0)

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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.


Willoughby, D., et al. J. Biol. Chem. 285(26):20328-20342(2010)
Chen, M.H., et al. Cell. Signal. 21(1):136-142(2009)
Tavalin, S.J. J. Biol. Chem. 283(17):11445-11452(2008)
Correia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)
Chai, S., et al. J. Biol. Chem. 282(31):22668-22677(2007)

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$ 295.00
$ 99.00
Cat# AP19171c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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