|Application ||WB, E|
|Other Accession||Q61488, NP_066382.1|
|Calculated MW||43577 Da|
|Antigen Region||195-223 aa|
|Other Names||Desert hedgehog protein, DHH, HHG-3, Desert hedgehog protein N-product, Desert hedgehog protein C-product, DHH|
|Target/Specificity||This DHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human DHH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DHH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.|
|Cellular Location||Desert hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note=The N-terminal peptide remains associated with the cell surface.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
Chinchilla, P., et al. Cell Cycle 9(3):570-579(2010)
Bishop, B., et al. Nat. Struct. Mol. Biol. 16(7):698-703(2009)
Hegde, G.V., et al. Mol. Cancer Res. 6(12):1928-1936(2008)
Nakamura, M., et al. Fukuoka Igaku Zasshi 99(5):102-106(2008)
Canto, P., et al. Mol. Hum. Reprod. 11(11):833-836(2005)
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