|Application ||WB, E|
|Calculated MW||79401 Da|
|Antigen Region||575-601 aa|
|Other Names||FYVE, RhoGEF and PH domain-containing protein 3, Zinc finger FYVE domain-containing protein 5, FGD3, ZFYVE5|
|Target/Specificity||This FGD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-601 amino acids from the C-terminal region of human FGD3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton|
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Provided below are standard protocols that you may find useful for product applications.
FGD3 promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Delague, V., et al. Am. J. Hum. Genet. 81(1):1-16(2007)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :
Salehi, A.H., et al. J. Biol. Chem. 277(50):48043-48050(2002)
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