|Application ||WB, E|
|Calculated MW||76107 Da|
|Antigen Region||40-68 aa|
|Other Names||Bestrophin-3, Vitelliform macular dystrophy 2-like protein 3, BEST3, VMD2L3|
|Target/Specificity||This BEST3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the N-terminal region of human BEST3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BEST3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina|
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Provided below are standard protocols that you may find useful for product applications.
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).
Marsey, L.L., et al. J. Physiol. (Lond.) 587 (PT 10), 2211-2224 (2009) :
Qu, Z.Q., et al. J. Biol. Chem. 282(24):17460-17467(2007)
Tsunenari, T., et al. J. Biol. Chem. 278(42):41114-41125(2003)
Stohr, H., et al. Eur. J. Hum. Genet. 10(4):281-284(2002)
Marquardt, A., et al. Hum. Mol. Genet. 7(9):1517-1525(1998)
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