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BEST3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BEST3 Antibody (N-term) AP19190a
    BEST3 Antibody (N-term) (Cat. #AP19190a) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the BEST3 antibody detected the BEST3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N1M1
Other Accession NP_116124.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 76107 Da
Antigen Region 40-68 aa
Additional Information
Gene ID 144453
Other Names Bestrophin-3, Vitelliform macular dystrophy 2-like protein 3, BEST3, VMD2L3
Target/Specificity This BEST3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the N-terminal region of human BEST3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBEST3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BEST3
Synonyms VMD2L3
Function Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina
Research Areas
Citations (0)

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BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).


Marsey, L.L., et al. J. Physiol. (Lond.) 587 (PT 10), 2211-2224 (2009) :
Qu, Z.Q., et al. J. Biol. Chem. 282(24):17460-17467(2007)
Tsunenari, T., et al. J. Biol. Chem. 278(42):41114-41125(2003)
Stohr, H., et al. Eur. J. Hum. Genet. 10(4):281-284(2002)
Marquardt, A., et al. Hum. Mol. Genet. 7(9):1517-1525(1998)

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$ 295.00
$ 99.00
Cat# AP19190a
(40 western blots)
Availability: In Stock
Bulk Size
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