|Application ||WB, E|
|Calculated MW||51976 Da|
|Antigen Region||163-189 aa|
|Other Names||Sorting and assembly machinery component 50 homolog, Transformation-related gene 3 protein, TRG-3, SAMM50, SAM50|
|Target/Specificity||This SAMM50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-189 amino acids from the Central region of human SAMM50.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAMM50 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be required for the assembly pathway of mitochondrial outer membrane proteins.|
|Cellular Location||Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
SAMM50 is a component of the sorting and assembly machinery (SAM) complex of the outer mitochondrial membrane. The SAM complex has a role in integrating beta-barrel proteins into the outer mitochondrial membrane (Humphries et al., 2005 [PubMed 15644312]).
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)
Xie, J., et al. FEBS Lett. 581(18):3545-3549(2007)
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