|Application ||WB, E|
|Calculated MW||30063 Da|
|Antigen Region||1-30 aa|
|Other Names||Fructose-2, 6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5|
|Target/Specificity||This TIGAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TIGAR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIGAR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq].
Bensaad, K., et al. EMBO J. 28(19):3015-3026(2009)
Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)
Lopez-Guerra, M., et al. Haematologica 93(12):1843-1851(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Bensaad, K., et al. Cell 126(1):107-120(2006)
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