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>   home   >   Products   >   Primary Antibodies   >   Mouse Mcm2 Antibody (C-term)   

Mouse Mcm2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Mcm2 Antibody (C-term) AP19218B
    Mouse Mcm2 Antibody (C-term) (Cat. #AP19218b) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Mcm2 antibody detected the Mcm2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P97310
Other Accession NP_032590.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 102078 Da
Antigen Region 713-742 aa
Additional Information
Gene ID 17216
Other Names DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, Mcm2, Bm28, Cdcl1, Kiaa0030, Mcmd2
Target/Specificity This Mouse Mcm2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713-742 amino acids from the C-terminal region of mouse Mcm2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Mcm2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mcm2
Synonyms Bm28, Cdcl1, Kiaa0030, Mcmd2
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
Cellular Location Nucleus.
Citations (0)

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Background

Mcm2 acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

References

Kunnev, D., et al. Oncogene 29(25):3630-3638(2010)
Chuang, C.H., et al. PLoS Genet. 6 (9) (2010) :
Lee, E.Y., et al. Dev. Biol. 332(1):104-115(2009)
Hasegawa, M., et al. Leuk. Res. 33(8):1100-1107(2009)
Breunig, J.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(35):13127-13132(2008)

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$ 295.00
$ 99.00
Cat# AP19218B
Size:
Quantity:
(40 western blots)
Availability: In Stock
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