|Application ||WB, E|
|Calculated MW||102078 Da|
|Antigen Region||713-742 aa|
|Other Names||DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, Mcm2, Bm28, Cdcl1, Kiaa0030, Mcmd2|
|Target/Specificity||This Mouse Mcm2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713-742 amino acids from the C-terminal region of mouse Mcm2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Mcm2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Bm28, Cdcl1, Kiaa0030, Mcmd2|
|Function||Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.|
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Provided below are standard protocols that you may find useful for product applications.
Mcm2 acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.
Kunnev, D., et al. Oncogene 29(25):3630-3638(2010)
Chuang, C.H., et al. PLoS Genet. 6 (9) (2010) :
Lee, E.Y., et al. Dev. Biol. 332(1):104-115(2009)
Hasegawa, M., et al. Leuk. Res. 33(8):1100-1107(2009)
Breunig, J.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(35):13127-13132(2008)
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