|Application ||WB, E|
|Calculated MW||121188 Da|
|Antigen Region||236-264 aa|
|Other Names||Nuclear export mediator factor Nemf, Serologically defined colon cancer antigen 1 homolog, Nemf, Sdccag1|
|Target/Specificity||This Mouse Sdccag1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-264 amino acids from the N-terminal region of mouse Sdccag1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Sdccag1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Nemf is important for the stable association of Ltn1 to the complex. May indirectly play a role in nuclear export.|
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Provided below are standard protocols that you may find useful for product applications.
SDCG1, serologically defined colon cancer antigen 1, belongs to the SDCCAG1 family. 2 isoforms of the human protein are produced by alternative splicing.
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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