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Mouse Sash1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P59808 |
| Other Accession | NP_780364.3 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 135591 Da |
| Antigen Region | 870-896 aa |
| Gene ID | 70097 |
|---|---|
| Other Names | SAM and SH3 domain-containing protein 1, Sash1 |
| Target/Specificity | This Mouse Sash1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 870-896 amino acids from the C-terminal region of mouse Sash1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Sash1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Sash1 |
|---|---|
| Function | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O94885}. |
| Tissue Location | Expressed in the microvascular endothelium of various organs, as well as in parenchymal cells. Expressed in the endothelium but not lymphoid cells of spleen and thymus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Sash1 may have a role in a signaling pathway. Could act as a tumor suppressor.
References
Trinidad, J.C., et al. Mol. Cell Proteomics 5(5):914-922(2006)
Lindvall, J.M., et al. Cell. Immunol. 235(1):46-55(2005)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Okazaki, N., et al. DNA Res. 10(4):167-180(2003)
Carninci, P., et al. Genome Res. 13 (6B), 1273-1289 (2003) :
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