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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Mouse Sin3a Antibody (C-term)   

Mouse Sin3a Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Sin3a Antibody (C-term) AP19223B
    Mouse Sin3a Antibody (C-term) (Cat. #AP19223b) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Sin3a antibody detected the Sin3a protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q60520
Other Accession Q96ST3, NP_001103820.1
Reactivity Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 145088 Da
Antigen Region 1078-1106 aa
Additional Information
Gene ID 20466
Other Names Paired amphipathic helix protein Sin3a, Histone deacetylase complex subunit Sin3a, Transcriptional corepressor Sin3a, Sin3a, Kiaa4126
Target/Specificity This Mouse Sin3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1078-1106 amino acids from the C-terminal region of mouse Sin3a.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Sin3a Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sin3a
Synonyms Kiaa4126
Function Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.
Cellular Location Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.
Tissue Location Widely expressed. Highest levels in testis, lung and thymus
Research Areas
Citations (0)

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Sin3a acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.


Baltus, G.A., et al. J. Biol. Chem. 284(11):6998-7006(2009)
Anderson, D.M., et al. Dev. Dyn. 238(3):572-580(2009)
Chang, S., et al. J. Immunol. 181(12):8372-8381(2008)
van Oevelen, C., et al. Mol. Cell 32(3):359-370(2008)
Wilkinson, D.S., et al. Mol. Cell. Biol. 28(6):1988-1998(2008)

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$ 295.00
$ 99.00
Cat# AP19223B
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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