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Mouse Dcc Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Dcc Antibody (C-term) AP19225B
    Mouse Dcc Antibody (C-term) (Cat. #AP19225b) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Dcc antibody detected the Dcc protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P70211
Other Accession Q63155
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 158341 Da
Antigen Region 1391-1417 aa
Additional Information
Gene ID 13176
Other Names Netrin receptor DCC, Tumor suppressor protein DCC, Dcc
Target/Specificity This Mouse Dcc antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1391-1417 amino acids from the C-terminal region of mouse Dcc.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Dcc Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dcc
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location In the embryo, expressed at high levels in the developing brain and neural tube. In adult, highly expressed in brain with very low levels found in testis, heart and thymus Isoform C is expressed only in the embryo
Research Areas
Citations (0)

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Background

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

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$ 295.00
$ 99.00
Cat# AP19225B
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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