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>   home   >   Products   >   Primary Antibodies   >   Mouse Cbx5 Antibody (C-term)   

Mouse Cbx5 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Cbx5 Antibody (C-term) AP19229b
    Mouse Cbx5 Antibody (C-term) (Cat. #AP19229b) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Cbx5 antibody detected the Cbx5 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q61686
Other Accession P45973, NP_001070257.1
Reactivity Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22186 Da
Antigen Region 160-186 aa
Additional Information
Gene ID 12419
Other Names Chromobox protein homolog 5, Heterochromatin protein 1 homolog alpha, HP1 alpha, Cbx5, Hp1a
Target/Specificity This Mouse Cbx5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-186 amino acids from the C-terminal region of mouse Cbx5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Cbx5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cbx5
Synonyms Hp1a
Function Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity).
Cellular Location Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase
Citations (0)

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Background

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity).

References

Sun, Y., et al. Biophys. J. 99(4):1274-1283(2010)
Muller, K.P., et al. Biophys. J. 97(11):2876-2885(2009)
Dong, K.B., et al. EMBO J. 27(20):2691-2701(2008)
Villeneuve, L.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(26):9047-9052(2008)
Brancorsini, S., et al. Cell Cycle 7(10):1415-1422(2008)

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$ 295.00
$ 99.00
Cat# AP19229b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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